Monolith
Characterize your most challenging interactions
Knowing the strength of the interactions between key players will give you the insights you need to understand the details behind how biological systems work.
If you’re having difficulty studying challenging interactions that include membrane proteins, PROTACs, intrinsically disordered proteins (IDPs), or RNA-based therapeutics, you’ll need Monolith to characterize them.
Monolith measures the broadest range of binding affinities in-solution, using very little sample.
Biomolecular InteractionsMeasure high and low affinities in the same system
Broad application rangeProtein, small molecules, nucleic acids, vesicles, plaetlets and whole cells, virus particles and empty capsids
Retain native conformationImmobilization free, in-solution measurements
StoichiometryCalculate molecular ratios of binding partners
Low sample consumptionMinimal concentration (pM/nM) and small volume (<4 µl)
ThermodynamicsDerive ΔG, ΔH and ΔS from calculated Kds
Fast measurementAccess affinities (Kd) in 10 minutes
Capillary technologiesFree of fluidics, no regular maintenance
