The versatility of the E220evolution Focused-ultrasonicator makes it possible to bring the advantages of Adaptive Focused Acoustics® (AFA®) to numerous biological and chemical applications including: DNA and chromatin shearing, tissue homogenization, cell lysis, compound dissolution, and particle micronization. The E220evolution can be upgraded to an E220 capable of processing 1-96 samples/run or to an LE220 for high throughput processing without purchasing a new instrument.